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This pattern is also more closely aligned with evidence for central reward-system modulation, including reduced neural responsiveness to food cues and attenuation of activity in reward-related brain regions

There simply might be too much volume of food at the meal that it's literally overstuffing the stomach

Minerals and Bone Health: Calcium, Vitamin D, and Magnesium Rapid weight loss increases bone turnover risk, making calcium and vitamin D supplementation critical during tirzepatide therapy

After crossing the blood-brain barrier, Meglutide participates in the activity of the appetite regulation center

Clinical Studies Overview Of Clinical Studies The safety and effectiveness of insulin glargine given once-daily at bedtime was compared to that of once-daily and twice-daily NPH insulin in open-label, randomized, active-controlled, parallel studies of 2,327 adult patients and 349 pediatric patients with type 1 diabetes mellitus and 1,563 adult patients with type 2 diabetes mellitus (see Tables 9-11)

Thats an aspiration risk under general anesthesia